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KMID : 1098420070150020082
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Korean Journal of Medicinal Crop Science
2007 Volume.15 No. 2 p.82 ~ p.88
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Anticoagulation and Anticancer Constituents from Eugenia caryophyllata Thunb
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Han Kyung-Min
Kim Sung-Hoon
Baek Nam-In
Kim Dae-Keun
Kwon Byoung-Mog
Chung In-Sik
Ahn Eun-Mi
Kim Dong-Hyun
Lee Youn-Hyung
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Abstract
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From the EtOAc fraction of Eugenia caryophyllata, four compounds were isolated through activity-guided silica gel column chromatography, From the result of spectroscopic data including NMR, MS and IR, the chemical structures of the compounds were determined as 1-allyl-4-hydroxy-3-methoxybezene acetate (eugenol acetate, 1), 1-allyl-4-hydroxy-3-methoxybezene (eugenol, 2), acid (oleanolic acid, 3) and , acid (maslinic acid, 4). Compounds 3 and 4 were isolated for the first time from this plant. Also, compounds 1, 2 and 3 exhibited relatively high platelet aggregation inhibitory activity with the values of 0.24, 0.09 and 0.07 mM, respectively. Compound 2 significantly prolonged activated partial thromboplastin time (aPTT) with the value of seconds as compared to the control with the value of seconds at the concentration of 50 . Compounds 1 and 3 revealed inhibitory activity on farnesyl protein transferase (FPTase) with the values of 0.49 and 0.24 mM and compounds 1 and 2 highly inhibited the growth of rat-H-ras cells with the values of 6.63 and 5.70 , respectively.
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KEYWORD
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Eugenia caryophyllata, PLT aggregation, aPTT, FPTase, rat-H-ras, eugenol, eugenol acetate, oleanolic acid, maslinic acid
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